Revolving around four central - and intrinsically flawed - characters, 'Beautiful Losers' is the frank and humorous story of a nameless narrator, his wife Edith, their domineering friend and mentor 'F' and Catherine Tekakwitha, a mythic 17th-century Mohawk virgin saint. The complexities of this three-way love, pain and lust are sent spiralling by the death of Edith and 'F' at the novel's start, leading the damaged narrator to question the nature of love, sexuality and spirituality in a series of explicit flashbacks.